La Roja are preparing for Saturday's UEFA Nations League encounter against England at Wembley, which will be Luis Enrique's first game in charge since taking over as Julen Lopetegui's full-time replacement.
Isco, meanwhile, says Real Madrid are not missing Cristiano Ronaldo just yet.
"The fact we have been a reference over the past decade means that everyone knows our national team", said Luis Enrique.
It will be Spains first match since they were eliminated by hosts Russian Federation in the Second Round of the 2018 FIFA World Cup, and also England's first game since they lost to Belgium in the Third-Place match of the World Cup.
"I'm not really concerned about that", he said when asked about the possible reaction towards him from a capacity crowd.
They endured a nightmare World cup campaign when they were knocked out by unfancied hosts Russian Federation after Spain coach Julen Lopetegui was sacked on the eve of the tournament. "I never wanted to hurt a colleague on the pitch, so my conscience is really clear about what I did that night".More news: Woods, Mickelson, DeChambeau selected to U.S. Ryder Cup team
It was the same situation as happened in November, 2016, when he had his first call up due to an injury to Costa and his response was a fine goal at Wembley when he came on in the second half with Spain two goals down at the time against England.
Fernando Hierro was in temporary charge of 2010 World champions Spain in Russian Federation.
He has of course got a great personality and a great presence on the pitch.
"I have been here for many years but still feel very young and eager and want to continue winning with the national team, it is all good for the moment".
"I have already spoken about evolving the model in my presentation and that is what we are working on".