Just like in their first fight 11 months ago, Whittaker had to overcome an injury, saying he broke his hand in the first round.
At the time of writing, the terms of the contest are not clear but UFC President Dana White confirmed that the fight will take place while it remains to be seen whether a title will be on the line, whether it will be the main event or how many rounds it will be.
Romero dropped Whittaker a second time with a left hand in the fifth - but again, he survived.
Allow Romero a third chance at UFC gold?
However, because Yoel Romero missed weight by.2 lbs on Friday, he will not be eligible to win the promotions coveted middleweight championship.More news: Simona Halep beats Sloane Stephens to win French Open
There is no word from the UFC if the fight will proceed and how the purses will be divided.
"It's going to be a five-round fight". The win moves Jackson to 1-1 as pro and as a UFC fighter.
Whittaker, of Australia, survived the third, despite an onslaught of offense from Romero.
Check below for the top Twitter reactions to Whittaker's title defense against Romero at UFC 225.
"It is my humble opinion I did not lose tonight", Romero said. Now that he is on the sidelines working more and more with FOX Sports, the former UFC middleweight champion remains that way. Plus, a new interim champion was crowned in the form of Colby "Chaos" Covington.
Holly Holm fights Megan Anderson in a bout that could determine women's featherweight champion Cris Cyborg's next opponent. Dos Anjos (28-9) has been superb in his three fights since moving up from the lightweight division. "The Truth" stung Brooks on the feet, then landed in his guard, where he punched him at will for two full minutes, leaving his face a swollen, bruised mess.