One of his recurring protagonists, Nathan Zuckerman, is a novelist whose own writings have similarly upset many Jews.
His "maleness" offended many readers, with his 1969 book Portnoy's Complaint, about the young, middle-class, sex-obsessed Alexander Portnoy leaving critics happy and elders enraged.
The New York Times reports the cause of death was congestive heart failure, according to a close friend. He was a prolific and lauded writer whose novel American Pastoral won the Pulitzer Prize for Fiction in 1998.
"I decided that I was done with fiction", he said. Nine of his novels featured his fictional alter-ego, Nathan Zuckerman (The Ghost Writer, Zuckerman Unbound, Exit Ghost), exploring nearly every facet of his identity, from being Jewish to being a writer and a man. "As for how Trump threatens us, I would say that, like the anxious and fear-ridden families in my book, what is most terrifying is that he makes any and everything possible, including, of course, the nuclear catastrophe", he said.
He added: "Improbably, I had the honor of meeting Philip Roth just a few months ago to discuss an adaptation of Plot Against America".More news: DR Congo Ebola outbreak: World Health Organization holds crisis talk as cases spread
Novelist Philip Roth was presented with the National Humanities Medal in 2011.
Roth was widely considered the last living great, white, male American novelist, who along with Saul Bellow, Norman Mailer and John Updike helped define what it meant to be American in the latter half of the 20th century.
Roth has written an array of highly acclaimed books in his lifetime till 2012, after which he announced his retirement. The book was published by Virago Press, whose founder, Carmen Callil, was the same judge who quit years later from the Booker committee.
"I did not want to, did not intend to, and was not able to speak for American Jews; I surely did not deny, and no one questioned the fact, that I spoke to them, and I hope to others as well", Roth wrote in his essay "Writing About Jews".
Roth was married twice - to Margaret Martinson from 1959 to 1963, and to his long-time partner Claire Bloom from 1990 to 1994. "In my life I have had, in total, a couple of months of these completely wonderful days as a writer, and that is enough".
The writer, regarded as a leading chronicler of the American experience, produced more than 25 novels including American Pastoral, Sabbath's Theater and The Human Stain, in a career spanning six decades.
He first Wednesday Margaret Martinson Williams in 1959 but the couple divorced four years later. His book "When She Was Good" is said to be based in part of his life with Williams, who he said tricked into marriage by pretending she was pregnant. He was eighty-five years old.