Merkel noted in a speech Friday in the western German city of Muenster that it took 12 years of work to put together.
The 2014 global agreement, known as the Joint Comprehensive Plan of Action (JCPOA), is with Iran, the five permanent members of the U.N. Security Council and the European Union. Beyond the boundaries of Iran's labs, that breaking of this nation's word could be the most perilous side effect of Trump's action.
There are, however, signs that other suppliers from within the Organization of the Petroleum Exporting Countries (OPEC) will step up output to counter the Iran disruption.
He said the sanctions will sharply curtail sales of oil by Iran, which is now the world's fifth largest producer.
Trump's decisions on Russian Federation and now on Iran has put India on horns of dilemma. European Commission High Representative for Foreign Affairs Federica Mogherini said yesterday that the USA did not have the power to scrap the agreement altogether, and that the EU would continue to pursue it. "And we can't allow that to happen". "After closely interrogating everybody I could find in the White House, there is no enthusiasm for a military option in the United States", he added.
Part of his argument is over what it didn't cover, including Iran's involvement in wars in Syria and Yemen. Macron vigorously supports the deal and tried to persuade Trump to stay committed to it during a visit to Washington last month.
"I would advise Iran not to start their nuclear programme", Mr Trump said when he was asked about the potential consequences.More news: Zambia on increased alert after Ebola outbreak in DRC
Senior European figures insisted on Wednesday that the deal was not dead, despite the United States withdrawing from it.
Meanwhile, for nations contemplating striking their own sensitive deals with Mr Trump, such as North Korea, the withdrawal will increase suspicions they can not expect the United States to stick to worldwide agreements it signs.
Emma Ashford, a research fellow with the Cato Institute, a think tank in Washington, said in an analysis on Tuesday that by leaving the nuclear deal without offering any clear strategy or plan for an alternative, "Trump is opening Pandora's box, increasing the risks of escalation and bringing us gradually closer to conflict with Iran".
The lawmakers' anger is reflective of the feelings of Iranian Supreme Leader Ayatollah Khamenei.
Iranian President Hassan Rouhani ordered his diplomats to negotiate with their European, Russian and Chinese counterparts, though he threatened that Iran would commence unlimited uranium enrichment if the continued negotiations do not yield results within several weeks.
The Kremlin said: "They emphasised the importance in principle of the JCPOA for worldwide and regional security, as well as for global nonproliferation".