Liverpool are now third in the Premier League, 18 points adrift of Manchester City, but stand as the only side to defeat Pep Guardiola's team in the league this season and will clash with them again in Wednesday's Champions League quarter-final first leg.
Had things worked out differently De Bruyne and Salah could have been teammates.
Liverpool's Mohamed Salah celebrates scoring their first goal during the Premier League match between West Ham United and Liverpool, at London Stadium, in London, Britain, on November4, 2017.
The pair will go head-to-head in the quarter-finals of the Champions League on Wednesday and De Bruyne said: "You can not compare - it is impossible".
He told reporters: "If I said to my players that we are going to do something different, to change how we play, they would look at me and think, 'This guy is scared.' They would say, 'The manager doesn't trust himself'".
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"In Chelsea he didn't play too much, but in Roma he was wonderful", said Guardiola.
'I am very happy with myself, I am very pleased with how I have played, I didn't expect to be this good this season, to be honest.
This season has been the Mohamed Salah show in more ways than one, as the Egyptian forward has been able to make some remarkable strides in his first full season of competing in English football.
De Bruyne is set to be among the contenders to claim the individual honour, having helped City move within one victory of the Premier League title.
De Bruyne added: "Well, if I get it, it would be nice I think for the team and for me. You have someone like Mo who does the hardest part of the game, which is putting the ball in the back of the net", Henderson explained. "Our strikers are 20, 21-years-old and maybe we need more time, but that's why it is fantastic to see".