"I've definitely stubbed my toe and said s-t or something like that and my kids are like, 'Mom!'" she said.
"I mean I'm always willing to try anything", she says in the clip, after Kimmel asks her if she's taken any. What is your opinion on bleached assholes?'" Theron was quick to correct Oyelowo, saying, "That's not what I said. So maybe Theron's trying to convince real-life stoners that her performance in the movie is grounded in real-life cannabis experience.
The 41-year-old actor thinks Charlize's accident "broke the ice" between them and cemented their friendship, even though he didn't realise why she had ran out of the restaurant at first.
Unfortunately, Oyelowo and Theron wouldn't share exactly what had made her laugh to the point of urination but said it revolved around someone butchering his name.
"Last week she showed up at my house, literally drove in her little tennis outfit and brought me a little container and just left it on my kitchen table", Theron told Kimmel.More news: Eastern Ghouta aid convoy flees as Syrian regime continues bombardment
The Oscar-winning actress explained: "She said, "I went to the store by myself".
The Oscar-winning actress is now promoting her new comedy Gringo, in which she plays the tough boss of a drug company. The actress was pleasantly surprised when she learned that her mom went to the store and bought them herself.
As Theron revealed during a Thursday appearance on "The Late Late Show with James Corden" alongside "Gringo" co-stars David Oyelowo and Joel Edgerton, she lost control of her bladder when she first met her co-stars while having dinner in Mexico City - although she places the blame firmly on Oyelowo's hilarious storytelling skills.
"It totally works, it's wonderful", she said, adding, "You can't have [my mom], she's all mine". "So I kind of had to stop, but yeah, every once in awhile I would be around edibles and would try it, but it was still the same thing".
"Gringo" hits theaters on Friday. Watch the clip below for more on the film.