The singer was playing one of his residency shows in Caesar's Palace, Las Vegas when the incident occurred, and happened as he was playing his 1973 hit, Saturday's Alright (For Fighting).
In a statement given to E!
Eventually, it all became a bit too much for the "Rocket Man" who stormed off the stage whilst his band continued to play, only returning once the area had been cleared of his fans.
Moment before his exit on Thursday night, footage shows the 70-year-old appear to shout "f*** off" repeatedly at one concertgoer.
"This guy was rude, disruptive and had no care or respect for our show and so I let him know how I felt, then left the stage until they had removed him".More news: Prince Harry And Meghan Markle Inviting Public To Their Wedding
Music legend Elton John lost it Thursday night and almost brought his show to an impromptu end due to an encounter with an overzealous fan.
The security onstage stopped the first batch who stretched their arms towards him, but when others kept doing it, Sir Elton decided that he wasn't going to deal with it any longer, as seen in a video obtained by TMZ. He went off mic and clearly mouthed "fuck off" twice and then pushed his hand.
He continued the concert performing The Circle of Life from The Lion King.
He re-emerged shortly after a cool down backstage, but told fans that they had to stay off the stage.
The British singer announced in January that this will be his last world tour as he wants to spend more time with his children.